Biology and treatment of Richter syndrome
نویسندگان
چکیده
منابع مشابه
The efficacy of ibrutinib in the treatment of Richter syndrome.
Contribution: S.W., E.S., C.D.C., and I.B. performed experiments; C.A., S.A., and F.O.H. provided clinical data and clinical care for patient P1; H.P., N.M.-D., E.F.-W., S.M., W.-D.H., and W.H. provided clinical data and clinical care for P2; T.L. performed chimerism analysis on blood samples from P1; K.B. conceived the study and provided laboratory resources; K.B., S.W., E.S., and I.B. planned...
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Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). RS occurs in approximately 2% to 10% of CLL patients during the course of their disease, with a transformation rate of 0.5% to 1% per year. A combination of germline genetic characteristics, clinical features (eg, advanced...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-01-791376